Elliplex Inc - Service for Life Sciences
Delivery Affinity Constants and Drug Leads at Low Cost


Scientific publications on the technology

  1. J.P. Landry, J. Gregg, and X.D. Zhu, Label-free detection of microarrays of biomolecules using oblique-incidence reflectivity difference microscopy, Opt. Lett. 29, 581 (2004).
  2. X.D. Zhu, Comparison of two optical techniques for label-free detection of biomolecular microarrays on solids, Opt. Commun. 259, 751 (2005).
  3. J.P. Landry, J. J. Gray, M.K. O'Toole, and X.D. Zhu, Incidence-angle dependence of optical reflectivity difference from an ultrathin film on solid surface, Opt. Lett. 31, 531 (2005).
  4. X.D. Zhu, J.P. Landry, Y.S. Sun, J.P. Gregg, and K.S. Lam, Oblique-Incidence Reflectivity Difference Microscope for Label-Free High-Throughput Detection of Biochemical Reactions in Microarray Format, Appl. Opt. 46, 1890 (2007).
  5. Y.Y. Fei, J.P. Landry, Y.S. Sun, X.D. Zhu, J.T. Luo, X.B. Wang, and K.S. Lam, A novel high-throughput scanning microscope for label-free detection of proteins and small molecule chemical microarrays, Rev. Sci. Instrum. 79, 013708 (2008).
  6. J.P. Landry, Y.S. Sun, X.W. Guo and X.D. Zhu, A study of protein reactions with surface-bound molecular targets using oblique-incidence reflectivity difference microscope, Appl. Opt. 47, 3275 (2008).
  7. Y.S. Sun, J.P. Landry, Y.Y. Fei, J.T. Luo, X.B. Wang, K.S. Lam, and X.D. Zhu, Effect of fluorescently labeling protein probes on kinetics of protein-ligand reactions, Langmuir 24, 13399 (2008).
  8. Y.S. Sun, J.P. Landry, Y.Y. Fei, J.T. Luo, K.S. Lam, and X.D. Zhu, Macromolecular scaffolds for immobilization small molecule microarrays on solid supports in label-free detection of protein-ligand interactions, Analyt. Chem. 81, 5373 (2009).
  9. Y.Y. Fei, J.P. Landry, Y.S. Sun, X.D. Zhu, J.T. Luo, X.B. Wang, C.Y. Wu, K.S. Lam, Screening small molecule compound microarrays for protein ligands without fluorescence labeling with a high-throughput scanning microscope, J. Biomed. Opt. 15, 016018 (2010).
  10. Kai-Yin Lo, Yung-Shin Sun, James P. Landry, X.D. Zhu, and Wenbin Deng, Label-free detection of surface markers on stem cells by oblique-incidence reflectivity difference microscopy, BioTechniques 50, 381-388 (2011). 
  11. Y.Y. Fei, A. Schmidt, G. Bylund, D.X. Johansson, S. Henriksson, C. Lebrilla, J.V. Solnick, T. Boren, and X.D. Zhu, Use of Real-Tine, Label-free Analysis in Revealing Low-Affinity Binding to Blood Group Antigens by Helicobacter pylori, Analyt.. Chem. 83, 6336 - 6341 (2011).
  12. Y.Y. Fei, Y.S. Sun, Y.H. Li, K. Lau, H. Yu, H.A. Chokhawala, S.S. Huang, J.P. Landry, X. Chen, and X.D. Zhu, Fluorescence Labeling Agents Change Binding Profiles of Glycan-Binding Proteins, Molecular BioSystems 7, 3343 - 3352 (2011). 
  13. J.P. Landry, Y.Y. Fei, and X.D. Zhu, High Throughput, Label-free Screening Small Molecule Compound Libraries for Protein-Ligands using Combination of Small Molecule Microarrays and a Special Ellipsometry-based Optical Scanner, International Drug Discovery 6, 8 -13 (2012). 
  14. J.P. Landry, Y.Y. Fei, and X.D. Zhu, Simultaneous Measurement of 10,000 Protein-Ligand Affinity Constants Using Microarray-based Kinetic Constant Assays, Assay and Drug Development Technologies, Assay and Drug Development Technologies 10, 250 - 259 (2012).
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